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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK4
All Species:
16.97
Human Site:
S293
Identified Species:
33.94
UniProt:
P11802
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11802
NP_000066.1
303
33730
S293
A
F
R
A
L
Q
H
S
Y
L
H
K
D
E
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
S293
A
F
R
A
L
Q
H
S
Y
L
H
K
D
E
G
Dog
Lupus familis
XP_538252
303
33686
S293
A
F
R
A
L
Q
H
S
Y
L
Q
K
A
E
G
Cat
Felis silvestris
Mouse
Mus musculus
P30285
303
33732
S293
A
F
R
A
L
Q
H
S
Y
L
H
K
E
E
S
Rat
Rattus norvegicus
P35426
303
33780
S293
A
F
R
A
L
Q
H
S
Y
L
H
K
E
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001007893
326
36832
P298
A
Y
A
A
L
S
H
P
Y
F
H
D
L
E
K
Frog
Xenopus laevis
Q91727
319
35666
P293
A
S
D
A
L
L
H
P
F
F
A
D
D
P
Q
Zebra Danio
Brachydanio rerio
NP_001071245
297
33310
A289
K
R
I
S
A
L
N
A
L
D
H
P
F
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_391955
457
50351
H449
T
A
A
Q
A
L
R
H
R
Y
F
A
E
D
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
G298
A
E
Q
G
L
L
H
G
F
F
G
D
E
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
E285
A
R
Q
A
L
E
H
E
Y
F
K
D
L
E
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
E285
A
R
A
A
L
E
H
E
Y
F
K
D
L
G
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
97
N.A.
94.7
95
N.A.
N.A.
65.3
72
71.9
N.A.
N.A.
35.2
N.A.
48.7
Protein Similarity:
100
N.A.
99.6
97.6
N.A.
97
97.3
N.A.
N.A.
75.7
79.9
80.1
N.A.
N.A.
50.3
N.A.
60.8
P-Site Identity:
100
N.A.
100
86.6
N.A.
86.6
86.6
N.A.
N.A.
46.6
33.3
6.6
N.A.
N.A.
0
N.A.
26.6
P-Site Similarity:
100
N.A.
100
86.6
N.A.
93.3
93.3
N.A.
N.A.
53.3
40
26.6
N.A.
N.A.
13.3
N.A.
46.6
Percent
Protein Identity:
N.A.
43.8
N.A.
45.5
N.A.
N.A.
Protein Similarity:
N.A.
62.7
N.A.
64
N.A.
N.A.
P-Site Identity:
N.A.
40
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
84
9
25
75
17
0
0
9
0
0
9
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
0
0
9
0
42
25
9
9
% D
% Glu:
0
9
0
0
0
17
0
17
0
0
0
0
34
67
9
% E
% Phe:
0
42
0
0
0
0
0
0
17
42
9
0
9
9
0
% F
% Gly:
0
0
0
9
0
0
0
9
0
0
9
0
0
9
34
% G
% His:
0
0
0
0
0
0
84
9
0
0
50
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
17
42
0
0
9
% K
% Leu:
0
0
0
0
84
34
0
0
9
42
0
0
25
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
17
0
0
0
9
0
9
0
% P
% Gln:
0
0
17
9
0
42
0
0
0
0
9
0
0
0
9
% Q
% Arg:
0
25
42
0
0
0
9
0
9
0
0
0
0
0
0
% R
% Ser:
0
9
0
9
0
9
0
42
0
0
0
0
0
0
25
% S
% Thr:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
67
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _